HDF Kita is a server-based application that facilitates quick and cost-effective access to large collections of HDF5-encoded data remotely stored in the cloud (e.g. Amazon S3). Kita can slice through HDF5 files without the need to download the entire file locally. This results in greater performance and cost benefits. In addition, HDF Kita allows developers to use a new REST API and command line interface OR existing h5py and library SDK (e.g. C/C++) to seamlessly read and write HDF5 files in the cloud.